Whitmore pointed out his preliminary surprise that ‘even for an 80-year-old patient, higher upfront costs of intense TBI [traumatic brain injury] management would still be cost-effective when the huge benefits of intense treatment are factored in.’ He continued, ‘We hope that doctors will consider the results of the study when faced with your choice of how aggressive to be in older people TBI patient.’.. Aggressive treatment of serious TBI is cost-effective: Study Researchers in the Perelman School of Medicine at the University of Pennsylvania have demonstrated that aggressive treatment of severe traumatic human brain injury, which includes invasive monitoring of intracranial pressure and decompressive craniectomy, produces better patient outcomes than less aggressive measures and is cost-effective in individuals regardless of their age–even in individuals 80 years.5 years . 9; price, 0.004 per participant-month vs. 0.034 per participant-month; P=0.02) and at 12 months . 17; rate, 0.018 per participant-month vs. 0.027 per participant-month; P=0.19). Renal Outcomes at 12 and 1. 5 years A complete of 102 patients had major renal disease at baseline, that was defined as the current presence of at least one factor designated as a significant abnormality in the renal category of the BVAS/WG . A total of 51 sufferers in each treatment group met this prespecified criterion for main renal disease at baseline. 5 years. The magnitude of improvement in mean estimated creatinine clearance levels as time passes was similar in the two treatment groups .