They might not realize allergists are the medical mystery detectives with the expertise to find what is causing all sorts of uncommon allergic responses. Two abstracts shown at the American College of Allergy, Asthma and Immunology Annual Scientific Achieving illustrate how an allergic response can be the unpredicted clue in a medical mystery. In mystery #1, a 48 year-old woman sought the information of an allergist after two weeks of chapped, dried out, itchy and swollen lips. During her exam, the woman said that when her boyfriend recently died, she kissed his lips during the funeral. The very next day, she woke up with dry and chapped lips. She tried dealing with her lips with an over-the-counter lip balm, topical antibiotic and topical supplement E, which seemed to make her symptoms even worse.The risk of death decreased by 58 percent with nivolumab, as compared with dacarbazine, among untreated individuals with advanced melanoma previously. The survival benefit was constant across all the prespecified subgroups, including patients with poor prognostic factors. The 1-year survival rate associated with nivolumab in this study is consistent with the results in a phase 1 study15,16,22 and was significantly greater than the rate connected with dacarbazine. Dacarbazine was chosen as the comparator because, until recently, it had been a typical first-line treatment in lots of countries for individuals who had melanoma without a BRAF mutation. In this group of patients, only ipilimumab in combination with dacarbazine offers been connected with a survival advantage, in comparison with dacarbazine only, in a stage 3, controlled trial.5 When the present research was planned in 2012, ipilimumab was not approved for use as a initial-line treatment for advanced melanoma generally in most regions outside the USA.