today announced that its European partner Almirall, S.A. Submitted a Advertising Authorization Program to the European Medicines Agency for linaclotide, a guanylate cyclase type-C agonist, for the treating irritable bowel syndrome with constipation . The submission includes efficacy and protection data from a Stage 3 plan comprising two double-blind placebo-controlled trials measured against the endpoints needed by the EMA and two open-label long term security studies.#5 Ab Wheel The ab wheel or power wheel is just what it says it is. It is a steering wheel with a stay in between it. You utilize the ab wheel for roll outs basically, and this is an extremely challenging abdominal exercise. There are a huge selection of methods to work your abdominal muscles, and above are simply 5 good pieces to include in your ab workouts. An if you don’t have any ab exercise equipment available, the floor is an excellent option always. Some of the best ab exercises are bicycle crunches and the plank.